Interleukin 1 receptor antagonist gene polymorphism and restenosis after coronary angioplasty
نویسندگان
چکیده
منابع مشابه
Interleukin 1 receptor antagonist gene polymorphism and restenosis after coronary angioplasty.
BACKGROUND Percutaneous transluminal coronary angioplasty (PTCA) is limited by the recurrence of luminal stenosis, which occurs in up to 50% of procedures. It has been shown that patient specific factors, perhaps genes, contribute to this process. OBJECTIVE To determine whether completion of healing after PTCA is part of an acute self limiting inflammatory process and whether polymorphism at ...
متن کاملInterleukin-1 receptor antagonist gene polymorphism and coronary artery disease.
BACKGROUND Cytokine gene variations are contributory factors in inflammatory pathology. Allele frequencies of interleukin (IL)-1 cluster genes [IL-1A(-889), IL-1B(-511), IL-1B(+3953), IL-1RN Intron 2 VNTR] and tissue necrosis factor (TNF)-alpha gene [TNFA(-308)] were measured in healthy blood donors (healthy control subjects), patients with angiographically normal coronary arteries (patient con...
متن کاملInfluence of interleukin-1 receptor antagonist gene polymorphism on disease.
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring competitive inhibitor of interleukin-1 (IL-1)-induced proinflammatory activity. The IL-1RA gene is polymorphic, resulting in quantitative differences in both IL-1RA and IL-1beta production. Persons homozygous for allele 2 of the IL-1RA gene (IL1RN*2) have a more prolonged and more severe proinflammatory immune response than per...
متن کاملInterleukin-1 receptor antagonist gene polymorphism in epithelial ovarian cancer.
The development of malignant tumors is constituted by different immunological components. Interleukin (IL)-1 receptor antagonist (RA) is known to be critically involved in the carcinogenesis of different malignant solid tumors. Polymorphism of a specific gene can have an important effect on gene transcription, the stability of the mRNA, or the quantity and activity of the resulting protein. In ...
متن کاملThe E-selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty.
OBJECTIVES Coronary angioplasty remains plagued by the problem of restenosis. Genetic polymorphisms may contribute to the development of restenosis by mediating exaggerated inflammatory responses of the endothelium to angioplasty-induced injury. BACKGROUND The serine (Ser)-128-arginine (Arg) gene polymorphism of E-selectin has been implicated in the pathogenesis of coronary artery disease (CA...
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ژورنال
عنوان ژورنال: Heart
سال: 2001
ISSN: 0007-0769
DOI: 10.1136/heart.86.3.336